https://www.selleckchem.com/pr....oducts/SB-431542.htm
els in the sciatic nerve compared to the control group, whereas these effects were reversed by exercise and IGF-1. However, simultaneous treatment of diabetic rats with IGF-I and exercise did not have any synergistic effects. Conclusions These findings indicate that diabetes-induced neuropathy may in part be associated with decreased angiogenesis mediated by overproduction of TSP-1 and NF-Ƙb, as well as reduced production of VEGF-A proteins. The findings also showed that exercise and IGF-I can reduce neuropathy followed by increased a
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