https://www.selleckchem.com/pr....oducts/pclx-001-ddd8
Using the von Frey procedure to record mechanical paw withdrawal thresholds, we found that cast immobilization and chronic alcohol drinking separately and additively produced mechanical hyperalgesia observed 3 days after cast removal. We then examined neuroadaptations in AMPA GluR1 and NMDA NR1 glutamate channel subunits, extracellular signal-regulated kinase (ERK), and cAMP response element-binding protein (CRE in bilateral motor and cingulate cortex across all groups. Consistent with increased pain-related behavior, chroni
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