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Three different comparisons were performed regarding the locations, which revealed that the specificity did not change regarding the locations while the sensitivity of Loc3 was higher than that of Loc1 and Loc2. Conclusions The preliminary data of 4.5-year single-center study proved that the isthmus location may be more beneficial to estimate the malignancy on the basis of toposonographic laterality of the nodules with undetermined cytology. This notewothy outcome may be considered particularly for the challenging cases with undetermine
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