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Carbon ion radiotherapy (CIRT) happens to be applied in cancer treatment for over 25 years. Nonetheless, guidelines for dose-volume constraints haven't been set up yet. The purpose of this review would be to summarize the dose-volume constraints in CIRT for head-and-neck (HN) cancer which were determined through earlier clinical studies based on the Japanese designs for relative biological effectiveness (RBE). a literary works review ended up being carried out to recognize all constraints deter