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Medication For ADHD - What Are the Side Effects? Many people with ADHD experience improvements in their symptoms through medication. Each person's reaction to drugs is different, and side effects can be problematic. Methylphenidate is a stimulant. It increases the levels of a chemical in the brain that helps regulate the behavior and focus. Stimulant medication Stimulant medication improves concentration and attention for 70 to 80% of children and adults that use it. They affect the