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of osteoporosis in ovariectomized rats through effects that might involve both osteoblasts and osteoclasts. PURPOSE To investigate using a novel imaging approach - hyperpolarized (HP) 13C magnetic resonance imaging (MRI) for simultaneous metabolism and perfusion assessment - to evaluate early and does-dependent radiotherapy (RT) response in a prostate cancer mouse model. METHODS AND MATERIALS Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice (n = 18) underwent single-fraction RT (4 - 14 Gy steep dose across the tumor) and were ima
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