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Collectively, our findings uncover a hitherto unknown mechanism of homeostatic regulation of FREE1, and demonstrate a unique regulatory SINAT-FREE1 module that subtly regulates plant response to iron deficiency stress.Irritable bowel syndrome (IBS) affects 10%-15% of adults in the United States and 12% of the worldwide population. Gastroenterologists as well as primary care practitioners are likely to be the first resource for patients with gastrointestinal (GI) symptoms. IBS is difficult to diagnose, as it is a functional GI disorder, de