https://www.selleckchem.com/pr....oducts/resatorvid.ht
LGE also decreased the intracellular Ca levels ([Ca ] ) in fMLF-activated human neutrophils. However, a specific JNK inhibitor inhibited the fMLF-induced O generation and CD11b expression, but it had no effect on [Ca ] in human neutrophils. LGE exhibited anti-inflammatory activities in fMLF-activated human neutrophils. The pharmacological mechanisms of LGE-repressed neutrophilic inflammation were through two independent pathways, JNK signaling and calcium mobilization. Our results suggested that LGE holds the potential to be develope
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