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The estimated value of apparent clearance in a typical individual standardized by mean weight ranged between 0.24-0.56 L/h/kg, the inter-individual variability in clearance ranged between 7.0% and 35.1%. Half of the studies evaluated the performance of their developed models via external evaluation. In conclusion, substantial predictors of digoxin pharmacokinetics in the pediatric population in addition to model characteristics and evaluation techniques are presented. For clinicians, clearance could be predicted using age especially in

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