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Diabetic nephropathy (DN) is the major cause of end-stage renal disease. Resveratrol (RSV) has been shown to exert a renoprotective effect against DN, but despite research progress, the protective mechanisms of RSV have not been fully elucidated. Here, we demonstrated that RSV relieved a series of pathological characteristics of DN and attenuated oxidative stress and apoptosis in the renal tissues of diabetic (db/db) mice. In addition, RSV inhibited oxidative stress production and apoptosis in human podocytes exposed to high glucose. Furt
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