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Symptoms of sore throat result from oropharyngeal inflammation, for which prostaglandin E is a key mediator. Flurbiprofen is a non-steroidal anti-inflammatory that provides sore throat relief. The preliminary objective of this study was to develop an in vitro model for assessing prostaglandin E stimulation by viral and bacterial triggers. The primary objective was to investigate the effect of diluted flurbiprofen-containing lozenges on prostaglandin E concentrations in stimulated cells. Prostaglandin E production was stimulated in three

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