https://www.selleckchem.com/pr....oducts/miransertib.h
SD prolonged anxiety-like behavior regardless of injury and was associated with increased cortical Iba1 labeling in both Sham and TBI mice. Strikingly, TBI SD mice displayed increased number of CD45+ cells near the site if injury, enhanced cortical GFAP immunolabeling and persistent expression of Trem2 and Tlr4 7 DPI compared TBI mice. These results support the hypothesis that post-injury SD alters stress-immune pathways and alters inflammatory outcomes after TBI. These data provide new insight to the dynamic interplay between TBI,
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