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ADHD Medications - Stimulant Or Non Stimulant? Stimulant drugs are the most popular ADHD treatment, because they're the most studied and have a fast-acting effect. But they're not for everyone. These drugs increase the communication between nerves and the regions of the brain to lessen symptoms of ADHD. They can also have side effects like a loss of appetite and changes in heart rate or blood pressure. Stimulants The most commonly used medication to treat ADHD is stimulants. They are known for enh