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How Does ADHD Medication Work? When a neuron transmits a signal to another, it makes use of chemicals known as neurotransmitters. These chemicals must travel through the gap, which is known as a synapse. Some ADHD medications can increase the efficiency of these messages. They may help neurons release neurotransmitters more or slow the Reuptake (called Reuptake inhibitors). Doctors start people with ADHD on a low dose of medication and then observe their responses. They gr