https://www.selleckchem.com/pr....oducts/pf-06952229.h
Immune checkpoint expression on tumor-infiltrating lymphocytes (TILs) has a correlation with the outcome of neoadjuvant chemotherapy (NAC) in breast cancer. However, the reciprocal effect of these regimens on the quality and quantity of immune checkpoints has hitherto not been addressed. We aimed to evaluate the impact of three NAC regimens on TILs and immune checkpoints in a murine triple-negative breast cancer model. Syngeneic model of locally-advanced breast cancer was established in immunocompetent mice using a 4T1 cell line. Tu
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