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ADHD Medications For Adults Stimulants can help regulate levels of chemical messengers in the brain that regulate attention. They are considered first-line medications for ADHD. Although they're not to be taken regularly, they can have side effects such as headaches and trouble sleeping. To decrease impulsivity or hyperactivity Your doctor might prescribe guanfacine under brand names Tenex or Intuniv (Catapres). have a longer acting than stimulants. Stimulants Stimulants are the medications most often prescribed to treat ADHD. They boost an