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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are the first choice of ADHD medications, they with the most research-based backing behind them, and they are quick-acting. However, they're not suitable for everyone. These medications increase signaling between brain regions and nerves to reduce ADHD symptoms. can also trigger negative side effects, such as a loss of appetite and changes in blood pressure or heart rate. Stimulants The most commonly used medicatio