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At 3 and 6 months, fractured trabeculae, fibroblasts, and new blood capillaries were increased, indicating an absorption and repair process. Bone volume fraction of ROIs of Op-FHs was lower than in No-FHs at each time point (n = 4, 0.05) in histological evaluation. At 6 months, the maximum load of No-FHs was higher than Op-FHs (n = 4, 0.05). These findings indicate that early-stage ONFH can be induced in small tail Han sheep using cryogenic equipment. This animal model may be helpful in developing new treatment modalities for h
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