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Introduction of person pancreatic or colorectal cancer tumors cells as well as M1-polarized macrophages significantly inhibited cyst development and tumor-induced angiogenesis. Protein evaluation and antibody-based neutralization tests confirmed why these effects had been mediated through production of C-X-C motif chemokines (CXCL9), CXCL10 and CXCL11. By comparison, M2-macrophages mediated increased tumor cell migration to the vascularized chamber and failed to restrict cyst development or angiogenesis. In fac
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