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These include signaling pathways regarded as involving lung damage such as TNF signaling, MAPK signaling and chemokine signaling pathways. All 12 pathways tend to be targeted in COL-3 treated HCC515 cells, by which genetics such as for example RHOA, RAC2, FAS, CDC42 have paid off expression. CGP-60474 shares 11 of 12 pathways with COL-3 and typical target genes such as for example RHOA. In addition it exclusively targets other genes regarding lung damage, such CALR and MMP14. Conclusi
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