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We additionally estimate the degree of hypoxia-inducible factor-1α (HIF-1α), angiopoietin 1 (ANG-1), and vascular endothelial development element (VEGF). We also examined into how ED affected the differentiation of osteoclasts utilising a co-culture system witia suppression of osteoclast differentiation and inflammatory response.Edaravone could mitigate CFA via suppressing angiogenesis and inflammatory responses, that might be linked with the HIF-1α-VEGF