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Gene phrase assays showed increased proteolytic activity and diminished matrix deposition as possible systems outlining the decreased fibrotic capsule deposition and improved peri-implant muscle quality shown in past scientific studies making use of IL-4 eluting coatings. The pattern of M2-like gene appearance promoted by IL-4 was correlated with glycosaminoglycan manufacturing inside the web site of implantation at early stages of this host reaction
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