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2%-4.8% of HIV infections over 20 years; provision to high-risk individuals only has similar impact at lower total cost. The incremental cost per HIV infection averted is lower in high-risk vs. all-risk sub-populations within female adolescents ($507 vs. $4,537), male adolescents ($2,108 vs. $5,637), young women ($1,592 vs. $10,323) and young men ($2,605 vs. $7,715), becoming cost saving within 20 years for high-risk adolescents, young women, MSM and FSWs. CONCLUSIONS PrEP is an expensive prevention intervention, but uptake by those at h

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