https://www.selleckchem.com/products/LBH-589.html
PURPOSE Characterize the role of B-cells on HPV-associated cancer patient outcomes and determine the effects of radiation and PD-1 blockade on B-cell populations. EXPERIMENTAL DESIGN Tumor RNA sequencing data from over 800 HNSCC and cervical cancer patients, including a prospective validation cohort, was analyzed to study the impact of B-cell gene expression on overall survival. A novel murine model of HPV+ HNSCC was used to study the effects of PD-1 blockade and RT on B-cell activation, differentiation, and clonality including analysis
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