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The prediction of hypertensive disorders in pregnancy (HDP) mainly involves various aspects such as maternal characteristics and biomarkers. We aimed to study the effect of the HDP prediction model with or without placental growth factor (PlGF). This study used maternal factors and PlGF, and standardized the data uniformly. At 12-20 weeks, the comprehensive comparison of model quality with or without PlGF was conducted by logistic regression. The area under curve and the model accuracy of the model with PlGF were higher than those of the