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51-1.00g/d (HR=3.00, p=0.02) and 1.00g/d (HR=13.03, p0.001) in unadjusted Cox regression models. After adjusted for potential confounders, proteinuria 0.31-0.50 g/d (HR=3.70, p=0.04), 0.51-1.00 g/d (HR=3.67, p=0.02), and 1.00 g/d (HR=8.20, p0.001) remained to be significantly associated with higher risks of doubling of Scr, while only those with proteinuria 1.00g/d (HR=6.04, p=0.001) exhibited a markedly increased risk of ESRD. Patients with proteinuria levels 0.30g/d already have a higher risk of doubling of bas

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