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As COVID-19 vaccine distribution continues, policy makers are struggling to decide which groups should be prioritized for vaccination. To assess US adults' preferences regarding COVID-19 vaccine prioritization. This survey study involved 2 independent, online surveys of US adults aged 18 years and older, 1 conducted by Gallup from September 14 to 27, 2020, and the other conducted by the COVID Collaborative from September 19 to 25, 2020. Samples were weighted to reflect sociodemographic characteristics of the US population. Respondents wer