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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are the first choice of ADHD medications, they with the most research-based evidence behind them, and are quick-acting. However, they're not for everyone. These medications boost the communication between brain regions and nerves to decrease ADHD symptoms. They can also cause side effects like an appetite loss and changes in heart rate or blood pressure. Stimulants The most commonly used medication to treat