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Nonetheless, it remains questionable just how workout intensity regulates OA development. Here, a declining propensity for TGF-β1 ended up being predicted via bioinformatics analysis of microarray GSE57218 and validated in cartilage samples obtained from arthroplasty. Considering this, cyclic tensile strain or TGF-β1 input ended up being done on human being OA chondrocytes, and we also found that moderate-intensity mechanical loads safeguarded chondrocytes against pyroptosis. In this process, the heig
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