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05). CD34+SFCs were more frequent in cysts than in tumors. Ultrastructurally, CD34+SFCs were identified for the first time in odontogenic lesions and showed characteristic bipolar/dendritic morphology. Among examined stromal stem cell markers, only SOX2 distinguished tumors from cysts. CD34+SFCs may also contribute to the biological behavior of odontogenic lesions. Among examined stromal stem cell markers, only SOX2 distinguished tumors from cysts. CD34 + SFCs may also contribute to the biological behavior of odontogenic lesions.We descri