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Medication For ADHD - What Are the Side Effects? Many people with ADHD have a decrease in symptoms when they use medication. But each person reacts differently to different medications, and adverse effects can be a problem. Methylphenidate is a stimulant. It increases the levels of a brain chemical that helps regulate behavior and attention. Stimulant medication Stimulant medication improves attention and concentration for 70 to 80% of children and adults that use it. They work by altering the act