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A fixed dose of 1500 mg/d was necessary for /= 90% PTA at higher MICs considered SDD; however, this dose had elevated risks of ≥24.3 mg/L. Fixed doses were more likely to achieve a AUC/MIC of 27.43 than weight-based doses up to 12 mg/kg/d. However, fixed doses necessary for 90% PTA against SDD isolates with higher MICs were associated with elevated risks of toxicity. A reevaluation of Clinical Laboratory Standards Institute breakpoints may need to be considered, with an emphasis on lowering the SDD breakpoint to 1 mg/L. Fixed doses
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