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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression If someone suffers from both ADHD and anxiety or depression, addressing the first can usually improve the other. Mental health specialists prescribe antidepressants, stimulants for depression, or antidepressants, along with ADHD medication. Wellbutrin (bupropion), and Effexor, (venlafaxine), are the two most common antidepressants prescribed to treat ADHD "off-label". These medications boost level