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Purpose Clinical research suggests that transcranial direct current stimulation (tDCS) at bilateral supraorbital foramen and inferior orbital rim and nose intersections may facilitate rehabilitation after stroke. However, the underlying neurobiological mechanisms of tDCS remain poorly understood, impeding its clinical application. Here, we investigated the effect of tDCS applied after stroke on neural cells.Materials and methods Middle cerebral arterial occlusion (MCAO) reperfusion was induced in rats. Animals with comparable infarcts were

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