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The expression levels of miR-335-5p and JNK3 were significantly inversely correlated. Further, dual Luciferase assay verified the relationship between miR-335-5p and JNK3. Overexpression of miR-335-5p obviously decreased the protein levels of JNK3 and Aβ and inhibited apoptosis in SH-SY5Y/APPswe cells, whereas the inhibition of miR-335-5p obtained the opposite results. Moreover, the overexpression of miR-335-5p remarkably improved cognitive abilities of APP/PS1 mice. CONCLUSION The results revealed that the increased JNK3 expression, neg
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