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48, p = 0.0036), men (χ2 = 17.1, p less then 0.0001), and current and former smokers (χ2 = 19.2, p less then 0.0001). Notably, epidermal growth factor receptor (EGFR) mutation-positive lung cancer patients with high PAK1 expression showed higher mortality rates than those with low PAK1 expression (91.3% vs. 62.5%, p = 0.02). Therefore, PAK1 overexpression could serve as a molecular target for the treatment of EGFR mutation-positive lung cancer, especially among male patients and current/former smokers. Gender medicine permeates all sect
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