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Monoclonal antibodies are efficiently reduced by extracorporeal therapies and re-dosing is necessary to provide sufficient efficacy. In the case of serious adverse events such as immune-related adverse events, IA might be used to eliminate the monoclonal antibody. Measuring IgG levels might be a reasonable strategy for monitoring drug levels of monoclonal antibodies during IA. © 2020 The Authors. Journal of Clinical Apheresis published by Wiley Periodicals, Inc.BACKGROUND Although the toxic effects of prenatal alcohol exposure (PAE) on childre