https://www.selleckchem.com/pr....oducts/PCI-24781.htm
Type2 diabetes mellitus (T2DM) has long been considered a risk factor for Alzheimer's disease (ad). However, the molecular links between T2DM and ad remain obscure. Here, we reported that serum/glucocorticoid-regulated kinase1 (SGK1) is activated by administering a chronic high-fat diet (HFD), which increases the risk of T2DM, and thus promotes Tau pathology via the phosphorylation of tau at Ser214 and the activation of a key tau kinase, namely, GSK-3ß, forming SGK1-GSK-3ß-tau complex. SGK1 was activated under conditions of elevated g
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