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Length of poly IC molecule also influence IFNβ expression in response of RLR pathway. Short (LMW) poly IC induce stronger IFN-β expression in myeloid (macrophage and monocyte) cells. In contrast long (HMW) poly IC preferably elicit higher IFNβ expression in non-myeloid (fibroblast) cell. Therefore, MDA5 and RIG-1 plays an indispensable role in eliciting antiviral response in non- immune (fibroblast) host cell. Thus, stimulation of RLR pathway with suitable and potentially cell-type specific agonist molecules successfully elicit antivir
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