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The NAP and KET were still detected at trace levels in managed water, indicating the persistent existence in the liquid cycle. The TI values for NAP and DIA (influent and effluent) had been a lot more than 1, showing a risk of a teratogenic impact. The IBU, KET, and DIC had values of significantly less than 1, showing the risk of life-threatening embryo effects. The NAP and DIA is classified as real human Pregnancy Category C (2.1 TI ≥ 0.76). This work proved why the