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The resulting analysis revealed that developed hydrogel membranes exhibited good mechanical properties and tensile strength to withstand the external frictional stress while covering the wound, exceptional swelling properties and surface porosity for sustained release of encapsulated drug (amikacin). Antibacterial results showed that amikacin-loaded hydrogel membranes exhibited significantly higher zone of inhibition against S. aureus and P. aregnosa. In accordance with our hypothesis, excisional animal model showed significantly higher