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h consistent, high guideline adherence from 2010 to 2017. Health facilities with 0-19 beds were less likely to prescribe new AEDs and completely adhere to proposed guidelines.Although increasing intracellular proline under stressed condition could help the plants survive, treating plant with high level of proline under normal condition could be inhibitory to plant growth. Among other possible mechanisms, proline-induced mitochondrial reactive oxygen species (ROS) production due to electron overflow in mitochondria electron transport cha