https://www.selleckchem.com/pr....oducts/tc-s-7009.htm
The combination treatments were more effective in reducing the number of cancer colonies compared to 5-FU or docetaxel alone. The combination of metformin with 5-FU or docetaxel significantly reduced the number of cells expressing the Shh protein compared to the 5-FU alone or docetaxel alone. Interestingly, we found that the combination of metformin with docetaxel significantly down-regulated the mRNA levels of , , and in the AGS gastric cancer cell line compared to docetaxel alone. Overall, our data strongly support an important role
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