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Hippocratea africana root is used in African folk medicine for the treatment of several ailments, including pain and inflammation. To isolate anti-inflammatory and analgesic compounds from the roots of H. africana, with accompanying antioxidant potentials. Dichloromethane, ethyl acetate, and aqueous fractions of H. africana roots, and isolated compounds from the bioactive ethyl acetate fraction were evaluated for anti-inflammatory and analgesic activities using the xylene induced oedema in mice and thermal induced pain models, respectiv