https://www.selleckchem.com/pr....oducts/salinosporami
Additionally, soluble selectins, which bind T. cruzi, block transendothelial migration dose-dependently, implying that the pathogen bears selectin-binding ligand(s) that start transmigration. Furthermore, function-blocking antibodies against E- and P-selectins, which act on endothelial cells and not T. cruzi, are exquisite in preventing TEM. Thus, our results show that selectins can function as mediators of T. cruzi transendothelial transmigration, suggesting a pathogenic mechanism that allows homing in of t
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