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The combination of the four metabolites had good performance at discriminating CKD from healthy controls (AUC = 0.96) as well as discriminating low eGFR from high eGFR in CKD (AUC = 0.96). Combinations of TMAO and its precursors were associated with glomerular function and might be utilized in evaluation of CKD. Combinations of TMAO and its precursors were associated with glomerular function and might be utilized in evaluation of CKD. Breast cancer is the most common cancer diagnosed during childbearing age, and fertility preservation is