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The primary reason for such failures may be the complexity of identifying certain target tumefaction antigens that needs to be unique or overexpressed only because of the tumor cells compared to regular cells. The majority of the cyst antigens contained in cancer vaccines tend to be non-mutated overexpressed self-antigens, eliciting mainly T cells with low-affinity T cell receptors (TCR) not able to mediate a successful anti-tumor reaction. In this review, t