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ygenation goals do not lead to different mortalities in mechanically ventilated critically ill patients. The potential superiority of maintaining P aO2 in the range 70-150 mmHg remains to be validated. Evidence suggests that vascular inflammation and thrombosis may be important drivers of poor clinical outcomes in patients with COVID-19. We hypothesised that a significant decrease in the percentage of blood volume in vessels with a cross-sectional area between 1.25 and 5 mm relative to the total pulmonary blood volume (BV5%) on chest com