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001). The levels of the three were all significantly higher in severe acute pancreatitis (SAP) patients than in non-SAP patients (p0.001); meanwhile, patients with high levels had a worse prognosis than those with low levels (p0.05). In multivariate analysis adjusted for age and sex,high levels of PCT, HBP, and IL-6 were found to be independently associated withthe development of AP. It dramatically improved the diagnostic power of AP when PCT, HBP, and IL-6 were combined; high PCT, HBP, and IL-6levels within 3days of admission