https://www.selleckchem.com/pr....oducts/JNJ-7706621.h
Compared with that of the control, the 5mC level on the TAB2 promoter is downregulated in the LPS-stimulated cells which can be reversed by TET2-knockdown. These findings altogether suggest that LPS-upregulated TET2 enhances IL-1β expression through demethylating the promoter region of TAB2, the key member of the TLR4/MAPK signaling pathway, a previously unreported molecular mechanism in TET2-regulated expression of inflammatory factors.Kalliklectin is a unique fish-specific lectin, whose sequence is similar to the heavy chain of ma
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